One-carbon metabolite levels in mid-pregnancy and risks of conotruncal heart defects

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One-carbon metabolite levels in mid-pregnancy and risks of conotruncal heart defects.

BACKGROUND Evidence exists for an association between use of vitamin supplements with folic acid in early pregnancy and reduced risk for offspring with conotruncal heart defects. A few observations have been made about nutrients related to one-carbon metabolism other than folate. Our prospective study attempted to extend information on nutrition and conotruncal heart defects by measuring analyt...

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Conotruncal Heart Defects: Altered Tissue Morphology and Hemodynamics

1 Biomedical Engineering Program, College of Engineering and Computing, University of South Carolina, Columbia, SC 29208, USA 2 Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC 29209, USA 3 Department of Pediatrics (Neonatology), Neonatal-Perinatal Research Institute, Duke University Medical Center, Durham, NC 297710, USA 4 Department of Cell...

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Mid-pregnancy cotinine and risks of orofacial clefts and neural tube defects.

OBJECTIVE Past studies of cigarette smoking as a contributor to orofacial clefts and neural tube defects (NTDs) used self-reports of smoke exposures. We have correlated measurements of cotinine (a nicotine metabolite) in mid-pregnancy sera with clefts and NTDs. STUDY DESIGN From a repository of >180 000 mid-pregnancy serum specimens collected in California from 2003 to 2005 and linked to deli...

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ژورنال

عنوان ژورنال: Birth Defects Research Part A: Clinical and Molecular Teratology

سال: 2014

ISSN: 1542-0752

DOI: 10.1002/bdra.23224